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Sarah Krueger

Sarah Krueger

Assistant Professor

Department of Science

Coad Science Building
Room 202

301-447-5721

Sarah Krueger earned her Ph.D. in chemistry from the University of Illinois Urbana-Champaign under the mentorship of Prof. Steven C. Zimmerman. Her doctoral research focused on developing self-assembling therapeutic agents for myotonic dystrophy. She is a proud alumna of the Mount, having earned her Bachelor of Science in Chemistry and Biochemistry here.

Dr. Krueger joined the Mount faculty in Fall 2022. Her research lab works to develop small molecules that bind to nucleic acids. In the classroom and the research laboratory, Dr. Krueger is passionate about helping to make science, and higher education in general, welcoming and safe for everyone.

  • Ph.D. Chemistry, University of Illinois Urbana-Champaign
  • B.S. Chemistry & Biochemistry, Mount St. Mary's University
  • UIUC Women in Chemistry Inclusive Leadership Award
  • National Science Foundation Graduate Research Fellowship
  • Clare Boothe Luce Scholarship

Expertise

  • Organic Chemistry
  • Chemical Biology

Courses Taught

  • General Chemistry
  • Organic Chemistry

Krueger, S.B., Zimmerman, S.C. Dynamic Covalent Template-Guided Screen for Nucleic Acid-Targeting Agents. J Med Chem 2022, 65, 12417–12426.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01086

Krueger, S.B., Lanzendorf, A.N., Jeon, H., Zimmerman S.C. Selective and Reversible Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy. ChemBioChem, 2022, 23, e202200260.
https://doi.org/10.1002/cbic.202200260

Li, K., Krueger, S.B., Zimmerman, S.C. A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1. ChemMedChem 2021, 16, 2638-2644. – selected as a VIP.
https://doi.org/10.1002/cmdc.202100243

Hagler, L.D., Krueger, S.B., Luu, L.M., Lanzendorf, A.N., Mitchell, N.L., Vergara, J.I., Curet, L.D., Zimmerman, S.C. Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease. ACS Med. Chem. Lett. 2021, 12, 935-940.
https://doi.org/10.1021/acsmedchemlett.1c00064

Hagler, L.D., Luu, L.M., Tonelli, M., Lee, J., Hayes, S., Bonson, S.E., Vergara, J.I., Butcher, S.E., Zimmerman, S.C. Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors. Biochemistry 2020, 59, 3463-3472.
https://doi.org/10.1021/acs.biochem.0c00472

Chen, J., Li, K., Bonson S.E., Zimmerman, S.C. A Bioorthogonal Small Molecule Selective Polymeric “Clickase”. J. Am. Chem. Soc. 2020, 142, 13966-13973.
https://doi.org/10.1021/jacs.0c06553

Hagler, L.D., Bonson S.E., Kocheril, P.K., Zimmerman S.C. Assessing the Feasibility and Stability of U-base Flipping in RNA-Small Molecule Complexes Using Molecular Dynamics Simulations. Canadian Journal of Chemistry 2020, 98, 261-269.
https://doi.org/10.1139/cjc-2019-0421

Serrano, J.F., Lee, J.Y., Curet, L.D., Hagler, L.D., Bonson, S.E., Schuster, E.J., Zimmerman, S.C. Development of novel macrocyclic small molecules that target CTG trinucleotide repeats. Bioorganic & Medicinal Chemistry 2019, 27, 2978-2984.
https://doi.org/10.1016/j.bmc.2019.05.022

Research Description

Although traditional drug discovery efforts focus on developing protein binders, DNA and RNA targeting have recently come into focus as a therapeutic strategy for a range of diseases that cannot be treated by targeting at the protein level. The Krueger group seeks to develop small molecules that bind at nucleobase mismatch sites relevant to trinucleotide repeat diseases such as Huntington’s Disease. Dr. Krueger's students bring together synthetic organic chemistry, chemical biology, and computational chemistry to understand the interactions between small molecules and disease-relevant nucleic acid targets. If you are interested in talking to Dr. Krueger about joining her research lab, please send her an email.